Objective To examine the dose-response relation between reduction in dietary sodium and
blood pressure change and to explore the impact of intervention duration. Design …

Background Recent cohort studies show that salt intake below 6 g is associated with
increased mortality. These findings have not changed public recommendations to lower salt …

Background A reduction in salt intake lowers blood pressure (BP) and, thereby, reduces
cardiovascular risk. A recent meta‐analysis by Graudal implied that salt reduction had …

Hypertension is a heritable and major contributor to the global burden of disease. The sum
of rare and common genetic variants robustly identified so far explain only 1%–2% of the …

High sodium intake increases blood pressure and proteinuria, induces glomerular
hyperfiltration and blunts the response to RAAS blockade. Although recommended in …

Background The projected reduced mortality effect of reduced sodium intake in model-
based studies conflicts with the observed increased mortality associated with low sodium …

The evidence relating blood pressure to salt intake in humans originates from population
studies and randomized clinical trials of interventions on dietary salt intake. Estimates from …

Several studies reported sex differences in aldosterone. It is unknown whether these
differences are associated with differences in volume regulation. Therefore we studied both …

Background. Recent experimental findings demonstrate vascular endothelial growth factor C
(VEGF-C)-mediated water-free storage of salt in the interstitium, which prevents a salt …

In the kidneys, there is both blood flow through the capillaries and flow of pre-urine through
the tubuli and collecting ducts. We hypothesized that diffusion-weighted (DW) MRI measures …