The interconnected causes and consequences of sleep in the brain
LD Lewis - Science, 2021 - science.org
Sleep is essential for brain function in a surprisingly diverse set of ways. In the short term,
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
lack of sleep leads to impaired memory and attention; in the longer term, it produces …
Air pollution, glymphatic impairment, and Alzheimer's disease
R Hussain, U Graham, A Elder, M Nedergaard - Trends in Neurosciences, 2023 - cell.com
Epidemiological evidence demonstrates a link between air pollution exposure and the onset
and progression of cognitive impairment and Alzheimer's disease (AD). However, current …
and progression of cognitive impairment and Alzheimer's disease (AD). However, current …
Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans
SD Williams, B Setzer, NE Fultz, Z Valdiviezo… - PLoS …, 2023 - journals.plos.org
Cerebrospinal fluid (CSF) flow maintains healthy brain homeostasis, facilitating solute
transport and the exchange of brain waste products. CSF flow is thus important for brain …
transport and the exchange of brain waste products. CSF flow is thus important for brain …
A real-time in vivo clearance assay for quantification of glymphatic efflux
Glymphatic fluid transport eliminates metabolic waste from the brain including amyloid-β, yet
the methodology for studying efflux remains rudimentary. Here, we develop a method to …
the methodology for studying efflux remains rudimentary. Here, we develop a method to …
Regional glymphatic abnormality in behavioral variant frontotemporal dementia
D Jiang, L Liu, Y Kong, Z Chen… - Annals of …, 2023 - Wiley Online Library
Objectives Glymphatic function has not yet been explored in behavioral variant
frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic …
frontotemporal dementia (bvFTD). The spatial correlation between regional glymphatic …
Resting-state global brain activity affects early β-amyloid accumulation in default mode network
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer's disease
(AD), first accumulates cortically in the default mode network (DMN), years before AD …
(AD), first accumulates cortically in the default mode network (DMN), years before AD …
Cerebral microcirculation, perivascular unit, and glymphatic system: role of aquaporin-4 as the gatekeeper for water homeostasis
J Szczygielski, M Kopańska, A Wysocka… - Frontiers in …, 2021 - frontiersin.org
In the past, water homeostasis of the brain was understood as a certain quantitative
equilibrium of water content between intravascular, interstitial, and intracellular spaces …
equilibrium of water content between intravascular, interstitial, and intracellular spaces …
Wide-spread brain activation and reduced CSF flow during avian REM sleep
G Ungurean, M Behroozi, L Böger, X Helluy… - Nature …, 2023 - nature.com
Mammalian sleep has been implicated in maintaining a healthy extracellular environment in
the brain. During wakefulness, neuronal activity leads to the accumulation of toxic proteins …
the brain. During wakefulness, neuronal activity leads to the accumulation of toxic proteins …
[HTML][HTML] Novel developments in non-contrast enhanced MRI of the perivascular clearance system: What are the possibilities for Alzheimer's disease research?
MM van der Thiel, WH Backes, IHGB Ramakers… - Neuroscience & …, 2023 - Elsevier
The cerebral waste clearance system (ie, glymphatic or intramural periarterial drainage)
works through a network of perivascular spaces (PVS). Dysfunction of this system likely …
works through a network of perivascular spaces (PVS). Dysfunction of this system likely …
Glymphatic system dysfunction: a novel mediator of sleep disorders and headaches
T Yi, P Gao, T Zhu, H Yin, S Jin - Frontiers in Neurology, 2022 - frontiersin.org
Sleep contributes to the maintenance of overall health and well-being. There are a growing
number of patients who have headache disorders that are significantly affected by poor …
number of patients who have headache disorders that are significantly affected by poor …