Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria
at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is …

Embryo implantation involves the intimate interaction between an implantation-competent
blastocyst and a receptive uterus, which occurs in a limited time period known as the …

This review considers how our understanding of preimplantation embryo metabolism has
progressed since the pioneering work on this topic in the late 1960s and early 1970s …

Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

Male obesity is associated with reduced sperm motility and morphology and increased
sperm DNA damage and oxidative stress; however, the reversibility of these phenotypes has …

Intrauterine growth restriction (IUGR) and pregnancy hypertensive disorders such as
preeclampsia (PE) associated with IUGR share a common placental phenotype called …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

The mammalian blastocyst exhibits an idiosyncratic metabolism, reflecting its unique
physiology and its ability to undergo implantation. Glucose is the primary nutrient of the …

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte
quality which is important for fertilization and development into viable offspring. Quality …