Metformin: a novel weapon against inflammation

B Bai, H Chen - Frontiers in pharmacology, 2021 - frontiersin.org
It has become widely accepted that inflammation is a driving force behind a variety of
chronic diseases, such as cardiovascular disease, diabetes, kidney disease, cancer …

Metformin for cardiovascular protection, inflammatory bowel disease, osteoporosis, periodontitis, polycystic ovarian syndrome, neurodegeneration, cancer …

M Ala, M Ala - ACS pharmacology & translational science, 2021 - ACS Publications
Diabetes is accompanied by several complications. Higher prevalence of cancers,
cardiovascular diseases, chronic kidney disease (CKD), obesity, osteoporosis, and …

Serum albumin levels: a biomarker to be repurposed in different disease settings in clinical practice

E Gremese, D Bruno, V Varriano, S Perniola… - Journal of Clinical …, 2023 - mdpi.com
Serum albumin (ALB), one of the most important proteins in human physiology, has the main
functions of maintaining plasma oncotic pressure and plasma volume, transporting …

Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway

X Gao, N Guo, H Xu, T Pan, A Yan, Y Mi, L Xu - Anti-cancer …, 2020 - journals.lww.com
Ferroptosis is a newly discovered type of cell death decided by iron-dependent lipid
peroxidation, but its role in glioblastoma cell death remains unclear. Ibuprofen, a …

Polymorphism of toll-like receptor genes and autoimmune endocrine diseases

KA Dvornikova, EY Bystrova, ON Platonova… - Autoimmunity …, 2020 - Elsevier
In recent years, there has been a significant amount of interest and vigorous studies on
mutations related to innate immunity receptor genes such as Toll-like receptors (TLR), which …

Type 2 diabetes mellitus and cancer: Epidemiology, physiopathology and prevention

C Rey-Reñones, JM Baena-Díez, I Aguilar-Palacio… - Biomedicines, 2021 - mdpi.com
Individuals with type 2 diabetes mellitus are at greater risk of developing cancer and of dying
from it. Both diseases are age-related, contributing to the impact of population aging on the …

[HTML][HTML] Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects

R Veeramachaneni, W Yu, JM Newton… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Metformin is a commonly used antidiabetic medication which has demonstrated
promise as an anticancer agent alone and in combination with conventional treatment …

[HTML][HTML] The Relationship between metformin consumption and cancer risk: an updated umbrella review of systematic reviews and meta-analyses

F Najafi, F Rajati, D Sarokhani… - … Journal of Preventive …, 2023 - journals.lww.com
Background: Considering that metformin is widely used in the treatment of diabetes, and its
protective role against various malignancies, the strength and validity of the available …

Autoimmune diseases and hematological malignancies: exploring the underlying mechanisms from epidemiological evidence

K Hemminki, W Huang, J Sundquist… - Seminars in cancer …, 2020 - Elsevier
Autoimmune diseases are characterized by the irregular functioning of the immune system
that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune …

Effects of inflammatory and anti-inflammatory environments on the macrophage mitochondrial function

D Ji, J Yin, D Li, C Zhu, J Ye, Y Pan - Scientific Reports, 2020 - nature.com
Mitochondrial response to inflammation is crucial in the metabolic adaptation to infection.
This study aimed to explore the mitochondrial response under inflammatory and anti …