Resistance to cancer therapy is a major barrier to cancer management. Conventional views
have proposed that acquisition of resistance may result from genetic mutations. However …

The minimally—or non-invasive detection of circulating tumor-derived components in
biofluids, such as blood, liquid biopsy is a revolutionary approach with significant potential …

Intrauterine growth restriction (IUGR) affects 10–15% of all pregnancies worldwide. IUGR
may result from maternal, placental or fetal origin. Maternal malnutrition before and during …

Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-
threatening condition, is one of the most common diabetes-specific complications. Diabetic …

DNA replication during cell proliferation is 'vertical'copying, which reproduces an initial
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

Phthalates, as other endocrine disrupting chemicals (EDCs), may alter the homeostasis and
the action of hormones and signaling molecules, causing adverse health outcomes. This is …

Osteoporosis is a metabolic skeletal disorder in which bone mass is depleted and bone
structure is destroyed to the degree that bone becomes fragile and prone to fractures …

Abstract Development of cerebral small vessel disease, a major cause of stroke and
dementia, may be influenced by early life factors. It is unclear whether these relationships …

Consumption of bioactive compounds such as polyphenols, isothiocyanates, sulfur-
containing compounds and terpenoids, found in fruits and vegetables, is associated with …