Connexins are assembled into dodecamer intercellular channels, a collection of which is
termed a gap junction, and their canonical function allowing direct exchange of ions and …

The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …

A global protein interactome ensures the maintenance of regulatory, signaling and structural
processes in cells, but at the same time, aberrations in the repertoire of protein–protein …

Glioblastoma multiform (GBM) is a highly aggressive primary brain tumor. Exosomes derived
from glioma cells under a hypoxic microenvironment play an important role in tumor biology …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …

Dysregulation of gap junction intercellular communication (GJIC) is recognized as one of the
key hallmarks for identifying non-genotoxic carcinogens (NGTxC). Currently, there is a …

Renal disease is a major public health challenge since its prevalence has continuously
increased over the last decades. At the end stage, extrarenal replacement therapy and …

Radiation therapy is one of the most commonly used treatments for head and neck cancers,
but it often leads to radiation-induced brain injury. Patients with radiation-induced brain …

Simple Summary Cell-to-cell communication is important for tissue homeostasis and is, in
general, decreased in cancer cells. The αCT1 peptide mimics the regulatory cytoplasmic …

Gap junctions (GJs) are important in the regulation of cell growth, morphology, differentiation
and migration. However, recently, more attention has been paid to their role in the …