Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
[HTML][HTML] Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
[HTML][HTML] Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
The Aging Biomarker Consortium represents a new era for aging research in China
The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …
[HTML][HTML] Resurrection of endogenous retroviruses during aging reinforces senescence
Whether and how certain transposable elements with viral origins, such as endogenous
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the …
Aging hallmarks and progression and age-related diseases: a landscape view of research advancement
Aging is a dynamic, time-dependent process that is characterized by a gradual accumulation
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
of cell damage. Continual functional decline in the intrinsic ability of living organisms to …
SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B
Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its
intrinsic mechanisms have been largely unexplored in primates. In this study, we …
intrinsic mechanisms have been largely unexplored in primates. In this study, we …
m6A epitranscriptomic regulation of tissue homeostasis during primate aging
Abstract How N 6-methyladenosine (m6A), the most abundant mRNA modification,
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …
contributes to primate tissue homeostasis and physiological aging remains elusive. Here …
Single-cell transcriptomic atlas of mouse cochlear aging
Progressive functional deterioration in the cochlea is associated with age-related hearing
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …