Determining a multimodal aging clock in a cohort of Chinese women
Background Translating aging rejuvenation strategies into clinical practice has the potential
to address the unmet needs of the global aging population. However, to successfully do so …
to address the unmet needs of the global aging population. However, to successfully do so …
[HTML][HTML] Aging Process and Related Diseases
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …
physiological function and an increased risk of age-related diseases. While aging is a …
[HTML][HTML] The safety and anti-ageing effects of nicotinamide mononucleotide in human clinical trials: an update
Q Song, X Zhou, K Xu, S Liu, X Zhu, J Yang - Advances in nutrition, 2023 - Elsevier
The importance of nicotinamide adenine dinucleotide (NAD+) in human physiology is well
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …
recognized. As the NAD+ concentration in human skin, blood, liver, muscle and brain are …
[PDF][PDF] Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging
Age-dependent loss of skeletal muscle mass and function is a feature of sarcopenia, and
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …
increases the risk of many aging-related metabolic diseases. Here, we report phenotypic …
[HTML][HTML] Decoding aging hallmarks at the single-cell level
S Ma, X Chi, Y Cai, Z Ji, S Wang, J Ren… - Annual Review of …, 2023 - annualreviews.org
Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …
organs, and systems. The advancement of single-cell technologies and generation of rich …
[HTML][HTML] Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However,
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
the aging-associated molecular mechanisms remain unclear. Here, using physiologically …
[HTML][HTML] A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
Our understanding of the molecular basis for cellular senescence remains incomplete,
limiting the development of strategies to ameliorate age-related pathologies by preventing …
limiting the development of strategies to ameliorate age-related pathologies by preventing …
A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes
S Yang, C Liu, M Jiang, X Liu, L Geng, Y Zhang… - Protein & …, 2024 - academic.oup.com
Aging increases the risk of liver diseases and systemic susceptibility to aging-related
diseases. However, cell type-specific changes and the underlying mechanism of liver aging …
diseases. However, cell type-specific changes and the underlying mechanism of liver aging …
CHIT1-positive microglia drive motor neuron ageing in the primate spinal cord
Ageing is a critical factor in spinal-cord-associated disorders, yet the ageing-specific
mechanisms underlying this relationship remain poorly understood. Here, to address this …
mechanisms underlying this relationship remain poorly understood. Here, to address this …