Sickle cell disease (SCD), a distinctive and often overlooked illness in the 21st century, is a
congenital blood disorder characterized by considerable phenotypic diversity. It comprises a …

Primum non nocere! Can iron deficiency, an abnormality that causes anemia, benefit people
with sickle cell disease (SCD) who already have an anemia? The published literature we …

Introduction Sickle cell disease (SCD) is an inherited disorder characterised by
polymerisation of deoxygenated haemoglobin S and microvascular obstruction. The cardinal …

People living with sickle cell disease (SCD), hematologist advocates, public health
professionals, and nongovernment organizations have for years been sounding the alarm …

Sickle cell disease (SCD) is a com-mon monogenic disorder affecting many people across
the world and is highly prevalent in countries of sub-Saharan Africa, Central America and …

4 Thomson AM, McHugh TA, Oron AP, et al. Global, regional, and national prevalence and
mortality burden of sickle cell disease, 2000–2021: a systematic analysis from the Global …

Sickle cell disease affects millions of individuals worldwide, causing relentless end-organ
injury, episodic emergencies, and early mortality. Deficiencies in sickle cell disease …

Sickle cell disease (SCD) is a hereditary red cell disorder with a large disease burden at a
global level. In the United States and Europe, medicines may qualify for orphan designation …

Sickle cell disease (SCD) imposes a significant health burden, particularly in low-and middle-
income countries where healthcare professionals and resources are scarce. This opinion …

Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr.
Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for …