The pharmacology and clinical efficacy of antiseizure medications: from bromide salts to cenobamate and beyond
Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …
Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments
The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
Cation-chloride cotransporters in neuronal development, plasticity and disease
Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …
TFOS Lifestyle: Impact of elective medications and procedures on the ocular surface
The word “elective” refers to medications and procedures undertaken by choice or with a
lower grade of prioritization. Patients usually use elective medications or undergo elective …
lower grade of prioritization. Patients usually use elective medications or undergo elective …
Adverse drug reactions induced by valproic acid
RM Nanau, MG Neuman - Clinical biochemistry, 2013 - Elsevier
Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …
in epilepsy and psychiatric disorders. VPA has good efficacy and pharmacoeconomic …
Ketogenic diets, mitochondria, and neurological diseases
The ketogenic diet (KD) is a broad-spectrum therapy for medically intractable epilepsy and is
receiving growing attention as a potential treatment for neurological disorders arising in part …
receiving growing attention as a potential treatment for neurological disorders arising in part …
Comparative safety of antiseizure medication monotherapy for major malformations
Objective This study was undertaken to examine the comparative safety of antiseizure
medication (ASM) monotherapy in pregnancy with respect to risk of major congenital …
medication (ASM) monotherapy in pregnancy with respect to risk of major congenital …
[HTML][HTML] ATP and adenosine—Two players in the control of seizures and epilepsy development
Despite continuous advances in understanding the underlying pathogenesis of
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
hyperexcitable networks and lowered seizure thresholds, the treatment of epilepsy remains …
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
N Huber, S Korhonen, D Hoffmann, S Leskelä… - Molecular …, 2022 - nature.com
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
Maintenance therapy with second generation antipsychotics for bipolar disorder–a systematic review and meta-analysis
L Lindström, E Lindström, M Nilsson… - Journal of Affective …, 2017 - Elsevier
Background Second generations antipsychotics (SGA) are frequently used for maintenance
treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects …
treatment in bipolar disorder. We systematically reviewed the efficacy and long-term effects …