In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

Antibiotics are powerful drugs used in the treatment of bacterial infections. The inappropriate
use of these medicines has driven the dissemination of antibiotic resistance (AR) in most …

Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

CRISPR-Cas systems provide bacteria and archaea with an adaptive immune system that
targets foreign DNA. However, the xenogenic nature of immunity provided by CRISPR-Cas …

Over the last decades, there has been a dramatic global increase in multidrug-resistant
(MDR) pathogens particularly among Gram-negative bacteria (GNB). Pseudomonas …

Objectives To evaluate the efficacy of the recently launched β-lactam/β-lactamase inhibitor
combinations ceftazidime/avibactam and ceftolozane/tazobactam against ESBL-producing …

Multidrug-resistant Gram-negative bacteria such as Acinetobacter baumannii,
Pseudomonas aeruginosa, and members of the Enterobacterales order are a challenging …

Introduction: The emergence of multidrug-resistant bacterial pathogens has led to a global
public health emergency and novel therapeutic options and drug-delivery systems are …

Antibiotic resistance in Pseudomonas aeruginosa remains one of the most challenging
phenomena of everyday medical science. The universal spread of high-risk clones of …

Objectives Pseudomonas aeruginosa has intrinsic antibiotic resistance and the strong ability
to acquire additional resistance genes. However, a limited number of investigations provide …