Background Migraine is a highly prevalent primary headache disorder. Despite a high
burden of disease, key disease mechanisms are not entirely understood. Functional …

Background Adverse childhood experiences have been linked to increased multimorbidity,
with physical and mental health consequences throughout life. Chronic pain is often …

This study aimed to examine the effects of luteolin (LUT) on chronic neuropathic pain (NP)-
induced mood disorders (ie, anxiety and depression) by regulating oxidative stress …

In this study, we aimed to evaluate the anti-inflammatory and anti-apoptotic effects of
melatonin (MLT) on neuropathic pain (NP)-induced anxiety and depression in a rat model …

Chronic pain is a maladaptive condition affecting 7%− 10% of the population worldwide and
can be accompanied by depression, anxiety, and insomnia. In particular, chronic pain is …

Tapentadol is an analgesic compound that acts centrally to attenuate pain. Previous studies
have shown that tapentadol has dual mechanisms of action as a mu-opioid receptor agonist …

Autism spectrum disorder (ASD) is a neurodevelopmental disorder, which affects 1 in 44
children and may cause severe disabilities. Besides socio-communicational difficulties and …

This systematic review aims to find effectful healthcare strategies, with special focus on drug-
free interventions and physical therapy, as part of the treatment for sleep in patients with …

The hypothesis that pain can predispose to frailty development has been recently
investigated in several clinical studies suggesting that frailty and pain may share some …

Inflammatory processes are increased by stress and contribute to the pathology of mood
disorders. Stress is thought to primarily induce inflammation through peripheral and central …