Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Beta-lactams remain a critical member of our antibiotic armamentarium and are among the
most commonly prescribed antibiotic classes in the inpatient setting. For these agents, the …

Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …

Purpose: In the present narrative review, the authors aimed to discuss the relationship
between the pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics and clinical …

Objectives To evaluate the association between early and cumulative beta-lactam
pharmacokinetic/pharmacodynamic (PK/PD) parameters and therapy outcomes in …

Objectives Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but
breakpoints of target attainment are mostly based on expert opinions. Studies that show a …

Purpose Inadequate piperacillin (PIP) exposure in intensive care unit (ICU) patients
threatens therapeutic success. Model-informed precision dosing (MIPD) might be promising …

SUMMARY The World Health Organisation's 2022 AWaRe Book provides guidance for the
use of 39 antibiotics to treat 35 infections in primary healthcare and hospital facilities. We …

Intravenous beta-lactam antibiotics are the most prescribed antibiotic class in US
hospitalized patients of all ages; therefore, optimizing their dosing is crucial. Bactericidal …

Pseudomonas aeruginosa (PA), a non–lactose-fermenting gram-negative bacillus, is a
common cause of nosocomial infections in critically ill or debilitated patients, particularly …