Necrotizing enterocolitis, gut microbes, and sepsis

JW Duess, ME Sampah, CM Lopez, K Tsuboi… - Gut …, 2023 - Taylor & Francis
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants and the
leading cause of death and disability from gastrointestinal disease in this vulnerable …

Emerging biomarkers for prediction and early diagnosis of necrotizing enterocolitis in the era of metabolomics and proteomics

E Agakidou, C Agakidis, H Gika, K Sarafidis - Frontiers in Pediatrics, 2020 - frontiersin.org
Necrotizing Enterocolitis (NEC) is a catastrophic disease affecting predominantly premature
infants and is characterized by high mortality and serious long-term consequences …

Toll-like receptor 4–mediated enteric glia loss is critical for the development of necrotizing enterocolitis

ML Kovler, AJ Gonzalez Salazar, WB Fulton… - Science translational …, 2021 - science.org
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants, whose
pathogenesis remains incompletely understood, although activation of the Gram-negative …

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Y Koike, B Li, N Ganji, H Zhu, H Miyake, Y Chen… - Nature …, 2020 - nature.com
Necrotizing enterocolitis (NEC) is a devastating disease of premature infants with high
mortality rate, indicating the need for precision treatment. NEC is characterized by intestinal …

Hypoxia: the “invisible pusher” of gut microbiota

N Han, Z Pan, G Liu, R Yang, B Yujing - Frontiers in Microbiology, 2021 - frontiersin.org
Oxygen is important to the human body. Cell survival and operations depend on oxygen.
When the body becomes hypoxic, it affects the organs, tissues and cells and can cause …

Evaluation of risk and preventive factors for necrotizing enterocolitis in premature newborns. A systematic review of the literature

AM Campos-Martinez, J Expósito-Herrera… - Frontiers in …, 2022 - frontiersin.org
Necrotizing enterocolitis (NEC) is a serious condition related to prematurity and the initiation
of enteral feeding. In this article, we review the evidence published in recent years on …

[HTML][HTML] Necrotizing enterocolitis in premature infants—A defect in the brakes? Evidence from clinical and animal studies

V Sampath, M Martinez, M Caplan, MA Underwood… - Mucosal …, 2023 - Elsevier
A key aspect of postnatal intestinal adaptation is the establishment of symbiotic relationships
with co-evolved gut microbiota. Necrotizing enterocolitis (NEC) is the most severe disease …

Antibiotics and the developing intestinal microbiome, metabolome and inflammatory environment in a randomized trial of preterm infants

JT Russell, J Lauren Ruoss, D de la Cruz, N Li… - Scientific Reports, 2021 - nature.com
Antibiotic use in neonates can have detrimental effects on the developing gut microbiome,
increasing the risk of morbidity. A majority of preterm neonates receive antibiotics after birth …

Impact of total parenteral nutrition on gut microbiota in pediatric population suffering intestinal disorders

T Cerdó, JA García-Santos, A Rodríguez-Pöhnlein… - Nutrients, 2022 - mdpi.com
Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with
digestive tract complications, particularly in preterm neonates due to their gut immaturity …

Multiomics Study Reveals Enterococcus and Subdoligranulum Are Beneficial to Necrotizing Enterocolitis

H Lin, Q Guo, Y Ran, L Lin, P Chen, J He… - Frontiers in …, 2021 - frontiersin.org
Necrotizing enterocolitis (NEC) is a life-threatening disease for premature infants with low
body weight. Due to its fragile gut microbiome and successful treatment of fecal microbiota …