The role of DNA methylation and DNA methyltransferases in cancer
DJ Weisenberger, R Lakshminarasimhan… - … -Role and Function, 2022 - Springer
The malignant transformation of normal cells is driven by both genetic and epigenetic
changes. With the advent of next-generation sequencing and large-scale international …
changes. With the advent of next-generation sequencing and large-scale international …
Predicting active enhancers with DNA methylation and histone modification
X Luo, Q Li, Y Tang, Y Liu, Q Zou, J Zheng, Y Zhang… - BMC …, 2023 - Springer
Background Enhancers play a crucial role in gene regulation, and some active enhancers
produce noncoding RNAs known as enhancer RNAs (eRNAs) bi-directionally. The most …
produce noncoding RNAs known as enhancer RNAs (eRNAs) bi-directionally. The most …
Integrating the epigenome and transcriptome of hepatocellular carcinoma to identify systematic enhancer aberrations and establish an aberrant enhancer-related …
P Huang, B Zhang, J Zhao, MD Li - Frontiers in cell and …, 2022 - frontiersin.org
Recently, emerging evidence has indicated that aberrant enhancers, especially super-
enhancers, play pivotal roles in the transcriptional reprogramming of multiple cancers …
enhancers, play pivotal roles in the transcriptional reprogramming of multiple cancers …
DNA methylation regulator-based molecular subtyping and tumor microenvironment characterization in hepatocellular carcinoma
J Zhao, Z Liu, K Yang, S Shen, J Peng - Frontiers in Immunology, 2024 - frontiersin.org
Backgroud Although recent studies have reported the regulation of the immune response in
hepatocellular carcinoma (HCC) through DNA methylation, the comprehensive impact …
hepatocellular carcinoma (HCC) through DNA methylation, the comprehensive impact …
[HTML][HTML] Methylome and transcriptome data integration reveals aberrantly regulated genes in equine sarcoids
E Semik-Gurgul, T Szmatoła, A Gurgul… - Biochimie, 2023 - Elsevier
DNA methylation is a key mechanism in transcription regulation, and aberrant methylation is
a common and important mechanism in tumor initiation, maintenance, and progression. To …
a common and important mechanism in tumor initiation, maintenance, and progression. To …
Multiomics Integration at Single-Cell Resolution Using Bayesian Networks: A Case Study in Hepatocellular Carcinoma
M Jihad, İ Yet - Omics: a journal of integrative biology, 2023 - liebertpub.com
Multiomics data integration is one of the leading frontiers of complex disease research and
integrative biology. The advances in single-cell sequencing technologies offer yet another …
integrative biology. The advances in single-cell sequencing technologies offer yet another …
Improving Infinium MethylationEPIC data processing: re-annotation of enhancers and long noncoding RNA genes and benchmarking of normalization methods
M Bizet, M Defrance, E Calonne, G Bontempi… - Epigenetics, 2022 - Taylor & Francis
ABSTRACT Illumina Infinium DNA Methylation (5mC) arrays are a popular technology for
low-cost, high-throughput, genome-scale measurement of 5mC distribution, especially in …
low-cost, high-throughput, genome-scale measurement of 5mC distribution, especially in …
DNA methylation and gene expression profiling highlight retinol metabolism's vital role in Hepatocellular carcinoma development
Y Zhao, K Wan, J Wang, S Wang, Y Chang, Z Du… - 2023 - researchsquare.com
Purpose Abnormal DNA methylation patterns play a critical role in the development of
hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with …
hepatocellular carcinoma (HCC). However, the molecular mechanisms associated with …
Improving Infinium MethylationEPIC data processing: focus on enhancers and long noncoding RNA genes
J Jeschke, M Bizet, M Defrance, E Calonne… - 2022 - researchsquare.com
Background Illumina Infinium DNA Methylation (5mC) profiling arrays are a popular
technology for low-cost, high-throughput, genome-scale measurement of 5mC distribution …
technology for low-cost, high-throughput, genome-scale measurement of 5mC distribution …
Enhancer-associated regulatory network and gene signature based on transcriptome and methylation data to predict the survival of patients with lung …
S Huang, S Chen, D Zhang, J Gao, L Liu - Frontiers in Genetics, 2022 - frontiersin.org
Accumulating evidence has proved that aberrant methylation of enhancers plays regulatory
roles in gene expression for various cancers including lung adenocarcinoma (LUAD). In this …
roles in gene expression for various cancers including lung adenocarcinoma (LUAD). In this …