Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives
Despite significant advancements made in the treatment of cancer during the past several
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …
decades, it remains one of the leading causes of death worldwide killing approximately 9.6 …
The role of natural products and their multitargeted approach to treat solid cancer
Natural products play a critical role in the discovery and development of numerous drugs for
the treatment of various types of cancer. These phytochemicals have demonstrated anti …
the treatment of various types of cancer. These phytochemicals have demonstrated anti …
[HTML][HTML] Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Z Turi, M Lacey, M Mistrik, P Moudry - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
The biosynthesis of ribosomes is a complex process that requires the coordinated action of
many factors and a huge energy investment from the cell. Ribosomes are essential for …
many factors and a huge energy investment from the cell. Ribosomes are essential for …
mTOR complex 2 signaling and functions
WJ Oh, E Jacinto - Cell cycle, 2011 - Taylor & Francis
The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression
N Lu, CJ Malemud - International journal of molecular sciences, 2019 - mdpi.com
Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …
Chemoresistance and the self-maintaining tumor microenvironment
G Yeldag, A Rice, A del Río Hernández - Cancers, 2018 - mdpi.com
The progression of cancer is associated with alterations in the tumor microenvironment,
including changes in extracellular matrix (ECM) composition, matrix rigidity …
including changes in extracellular matrix (ECM) composition, matrix rigidity …
Growing knowledge of the mTOR signaling network
K Huang, DC Fingar - Seminars in cell & developmental biology, 2014 - Elsevier
The kinase mTOR (mechanistic target of rapamycin) integrates diverse environmental
signals and translates these cues into appropriate cellular responses. mTOR forms the …
signals and translates these cues into appropriate cellular responses. mTOR forms the …
[HTML][HTML] Mechanistic target of rapamycin–independent antidepressant effects of (R)-ketamine in a social defeat stress model
Background The role of the mechanistic target of rapamycin (mTOR) signaling in the
antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal …
antidepressant effects of ketamine is controversial. In addition to mTOR, extracellular signal …
Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling
Summary mTORC1 is a signal integrator and master regulator of cellular anabolic processes
linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid …
linked to cell growth and survival. Here, we demonstrate that mTORC1 promotes lipid …
The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer
BM Slomovitz, RL Coleman - Clinical Cancer Research, 2012 - AACR
Endometrial cancer is the most common gynecologic malignancy in the United States.
Overactivation of the PI3K/AKT/mTOR pathway, a signaling pathway that plays an important …
Overactivation of the PI3K/AKT/mTOR pathway, a signaling pathway that plays an important …