MicroRNAs (miRNAs) have been shown to be dysregulated in virus-related cancers;
however, miRNA regulation of virus-related cancer development and progression remains …

Effective management of advanced urothelial bladder cancer is challenging. New
discoveries that improve our understanding of molecular bladder cancer subtypes have …

Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer and occurs mainly
in patients with liver cirrhosis. The mammalian target of rapamycin (mTOR) signaling …

Cancer often arises when normal cellular growth goes awry due to defects in critical signal
transduction pathways. A growing number of inhibitors that target specific components of …

Epstein–Barr virus (EBV; human herpesvirus 4; HHV‐4) and Kaposi sarcoma‐associated
herpesvirus (KSHV; human herpesvirus 8; HHV‐8) are human gammaherpesviruses that …

Background Ovarian cancer is one of the major causes of death in women worldwide.
Despite improvements in conventional treatment approaches, such as surgery and …

We investigated short-term effects (up to 24h) of air exposure and confinement, and long-
term effects (up to 11 days) of confinement, to elucidate signalling pathways in the stress …

The mechanistic target of rapamycin (mTOR) is a master regulator of the inflammatory
response in immune and non-immune cells. In immune cells mTOR regulates metabolism to …

Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell
states. The two states that bookend the pluripotency continuum, naive and primed, are well …

Neurodevelopmental disorders (NDDs) and cancer share proteins, pathways, and
mutations. Their clinical symptoms are different. However, individuals with NDDs have …