Vagus nerve stimulation (VNS) can modulate vagal activity and neuro-immune
communication. Human and animal studies have provided growing evidence that VNS can …

Objective Intracranial electrographic localization of the seizure onset zone (SOZ) can guide
surgical approaches for medically refractory epilepsy patients, especially when the …

Epigenetic mechanisms are involved in epilepsy and chronic pain development. About that,
we studied the effects of the natural histone deacetylase (HDAC) inhibitor sodium butyrate …

Due to the increasing use of local anesthetic techniques in various healthcare settings, local
anesthetic toxicity still occurs. Seizures are the most common symptom of local anesthetic …

Objective The hyperexcitable brain provides a common ground for comorbidity of pain
syndromes and epilepsy. There are controversial reports about pain sensitivity during the …

Aim Epilepsy is one of the most common neurological diseases. Dexketoprofen (DEX) is a
nonselective nonsteroidal anti-inflammatory drug that is used as an analgesic. The present …

Objective EGb 761, a plant extract obtained from the leaves of the Ginkgo biloba tree, is
widely used in modern medicine and traditional medicine applications in the treatment of …

We have recently identified several aroylhydrazone-based molecular hybrids with
antiseizure activity. We aimed to investigate the analgesic activity of these molecules further …

To examine comorbid pain sensitivity, temporal lobe epilepsy was modeled with a 42-
stimulation amygdala kindling paradigm using rats. Sham and kindled rats' mechanical …

GABA A receptors have long been known to be important modulators of pain but the
development of pain-modifying medicines based upon this mechanism has been hampered …