Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …

Schizophrenia was initially defined as “dementia praecox” by E. Kraepelin, which implies
progressive deterioration. However, recent studies have revealed that early effective …

Importance Diverse models have been developed to predict psychosis in patients with
clinical high-risk (CHR) states. Whether prediction can be improved by efficiently combining …

Anomalous patterns of brain gyrification have been reported in major psychiatric disorders,
presumably reflecting their neurodevelopmental pathology. However, previous reports …

To date, a large number of magnetic resonance imaging (MRI) studies have been conducted
in schizophrenia, which generally demonstrate gray matter reduction, predominantly in the …

Importance There is urgent need to improve the limited prognostic accuracy of clinical
instruments to predict psychosis onset in individuals at clinical high risk (CHR) for psychosis …

The cerebral cortex of the human brain has a complex morphological structure consisting of
folded or smooth cortical surfaces. These morphological features are referred to as cortical …

Schizophrenia is modelled as a neurodevelopmental disease with high heritability.
However, established markers like cortical thickness and grey matter volume are heavily …

Previous magnetic resonance imaging (MRI) studies reported increased brain gyrification in
schizophrenia and schizotypal disorder, a prototypic disorder within the schizophrenia …

Disrupted functional connectivity (FC) of the default mode network (DMN) may have a
pathophysiological role in schizophrenia. However, functional magnetic resonance imaging …