After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be
disposed in tissues where they do not exert clinically-relevant effects. Therapeutically …

NF-κB signaling is essential to an effective innate and adaptive immune response. Many
immune-specific functional and developmental outcomes depend in large on NF-κB. The …

For decades, it has been known that patients with certain autoimmune and inflammatory
disorders, such as rheumatoid arthritis (RA) and primary Sjögren's syndrome (pSS), have an …

Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several
autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and …

Purpose and methods B cell-activating factor (BAFF) contributes to the pathogenesis of
autoimmune diseases including systemic lupus erythematosus (SLE). Although several anti …

Toll-like receptor (TLR), a ligand for single-stranded RNA, has been implicated in the
development of pathogenic anti-RNA autoantibodies both in systemic lupus erythematous …

Primary Sjögren's syndrome is an autoimmune disorder with external exocrine glands
dysfunction and multiorgan involvement. The pathogenesis of primary Sjogren's syndrome is …

Myasthenia gravis (MG) is an autoimmune disease mediated by antibodies directed to
molecules of the endplate of the neuromuscular junction. B cells play a major role in MG …

The clearest evidence that B cells play an important role in human autoimmunity is that
immunotherapies that deplete B cells are very effective treatments for many autoimmune …

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease that is estimated to
affect 35 million people worldwide. Hallmarks of the disease are a loss of salivary and …