Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe

BS Hercyk, UN Onwubiko, ME Das - Molecular microbiology, 2019 - Wiley Online Library
During cytokinesis, animal and fungal cells form a membrane furrow via actomyosin ring
constriction. Our understanding of actomyosin ring‐driven cytokinesis stems extensively …

Transmembrane formins as active cargoes of membrane trafficking

F Cvrčková, R Ghosh, H Kočová - Journal of Experimental …, 2024 - academic.oup.com
Formins are a large, evolutionarily old family of cytoskeletal regulators whose roles include
actin capping and nucleation, as well as modulation of microtubule dynamics. The plant …

Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration

S Saha, JP Town, OD Weiner - Molecular biology of the cell, 2023 - Am Soc Cell Biol
By acting both upstream of and downstream from biochemical organizers of the
cytoskeleton, physical forces function as central integrators of cell shape and movement …

The intrinsically disordered region of the cytokinetic F-BAR protein Cdc15 performs a unique essential function in maintenance of cytokinetic ring integrity

MSC Mangione, CE Snider… - Molecular Biology of the …, 2019 - Am Soc Cell Biol
Successful separation of two daughter cells (ie, cytokinesis) is essential for life. Many
eukaryotic cells divide using a contractile apparatus called the cytokinetic ring (CR) that …

Cdc42 promotes Bgs1 recruitment for septum synthesis and glucanase localization for cell separation during cytokinesis in fission yeast

UN Onwubiko, J Rich-Robinson, RA Mustaf… - Small GTPases, 2021 - Taylor & Francis
Cytokinesis in fission yeast involves actomyosin ring constriction concurrent to septum
synthesis followed by septum digestion resulting in cell separation. A recent report indicates …

Cdc42 GTPase activating proteins Rga4 and Rga6 coordinate septum synthesis and membrane trafficking at the division plane during cytokinesis

BF Campbell, BS Hercyk, AR Williams, E San Miguel… - Traffic, 2022 - Wiley Online Library
Fission yeast cytokinesis is driven by simultaneous septum synthesis, membrane furrowing
and actomyosin ring constriction. The septum consists of a primary septum flanked by …

Cdc42 prevents precocious Rho1 activation during cytokinesis in a Pak1-dependent manner

UN Onwubiko, D Kalathil, E Koory… - Journal of Cell …, 2023 - journals.biologists.com
During cytokinesis, a series of coordinated events partition a dividing cell. Accurate
regulation of cytokinesis is essential for proliferation and genome integrity. In fission yeast …

The multiple functions of Rho GTPases in fission yeasts

J Vicente-Soler, T Soto, A Franco, J Cansado… - Cells, 2021 - mdpi.com
The Rho family of GTPases represents highly conserved molecular switches involved in a
plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has …

Rho family GTPases in fission yeast cytokinesis

B Hercyk, M Das - Communicative & integrative biology, 2019 - Taylor & Francis
During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho
GTPases drive this process through the positioning and assembly of the actomyosin ring …

F-BAR Cdc15 Promotes Cdc42 Activation During Cytokinesis and Cell Polarization in Schizosaccharomyces pombe

BS Hercyk, ME Das - Genetics, 2019 - academic.oup.com
Abstract Cdc42, a Rho-family GTPase, is a master regulator of cell polarity. Recently, it has
been shown that Cdc42 also facilitates proper cytokinesis in the fission yeast …