Mitochondrial abnormalities have been noted in lupus, but the causes and consequences
remain obscure. Autophagy-related genes ATG5, ATG7 and IRGM have been previously …

Highlights•Immunity-related GTPases (IRGs) specifically localize to and destroy pathogen-
containing vacuoles (PVs).•IRGs must differentiate PV membranes from host …

The human immunity-related GTPase M (IRGM) is a GTP-binding protein that regulates
selective autophagy including xenophagy and mitophagy. IRGM impacts autophagy by (1) …

Activation of the type 1 interferon response is extensively connected to the pathogenesis of
autoimmune diseases. Loss of function of Immunity Related GTPase M (IRGM) has also …

Abstract Inflammatory caspase‐11 (rodent) and caspases‐4/5 (humans) detect the Gram‐
negative bacterial component LPS within the host cell cytosol, promoting activation of the …

Mycobacterium tuberculosis (Mtb) defends host-mediated killing by repressing the
autophagolysosome machinery. For the first time, we report NCoR1 co-repressor as a …

As a cellular bulk degradation and survival mechanism, autophagy is implicated in diverse
biological processes. Genome-wide association studies have revealed the link between …

B lymphocytes are responsible for humoral immunity and play a key role in the immune
response. Optimal mitochondrial function is required to support B cell activity during …

Autophagy is a highly conserved process that utilizes lysosomes to selectively degrade a
variety of intracellular cargo, thus providing quality control over cellular components and …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung
disease. Many studies suggest that autophagy may be related to disease progression and …