Metformin; a review of its history and future: from lilac to longevity
I Thomas, B Gregg - Pediatric diabetes, 2017 - Wiley Online Library
Metformin is a widely prescribed medication that has been used to treat children with type 2
diabetes in the United States for the past 15 years. Metformin now has a variety of clinical …
diabetes in the United States for the past 15 years. Metformin now has a variety of clinical …
Common therapeutic advances for Duchenne muscular dystrophy (DMD)
A Salmaninejad, Y Jafari Abarghan… - International Journal …, 2021 - Taylor & Francis
Background and purpose: Duchenne muscular dystrophy (DMD), a lethal X-linked recessive
muscle dystrophy, is resulted in by different mutations including mostly frame-shifting gross …
muscle dystrophy, is resulted in by different mutations including mostly frame-shifting gross …
[HTML][HTML] Metformin delays satellite cell activation and maintains quiescence
The regeneration of the muscle tissue relies on the capacity of the satellite stem cell (SC)
population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age …
population to exit quiescence, divide asymmetrically, proliferate, and differentiate. In age …
Skeletal muscle metabolism in duchenne and becker muscular dystrophy—Implications for therapies
A Heydemann - Nutrients, 2018 - mdpi.com
The interactions between nutrition and metabolism and skeletal muscle have long been
known. Muscle is the major metabolic organ—it consumes more calories than other organs …
known. Muscle is the major metabolic organ—it consumes more calories than other organs …
Effect of a long-term treatment with metformin in dystrophic mdx mice: A reconsideration of its potential clinical interest in Duchenne muscular dystrophy
P Mantuano, F Sanarica, E Conte, MG Morgese… - Biochemical …, 2018 - Elsevier
The pharmacological stimulation of AMP-activated protein kinase (AMPK) via metabolic
enhancers has been proposed as potential therapeutic strategy for Duchenne muscular …
enhancers has been proposed as potential therapeutic strategy for Duchenne muscular …
Tamoxifen in Duchenne muscular dystrophy (TAMDMD): study protocol for a multicenter, randomized, placebo-controlled, double-blind phase 3 trial
S Nagy, P Hafner, S Schmidt, D Rubino-Nacht… - Trials, 2019 - Springer
Background Duchenne muscular dystrophy (DMD) is an inherited neuromuscular disorder of
childhood with a devastating disease course. Several targeted gene therapies and …
childhood with a devastating disease course. Several targeted gene therapies and …
Stable-Isotope Dilution GC–MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in …
S Baskal, A Bollenbach, B Henzi, P Hafner, D Fischer… - Molecules, 2022 - mdpi.com
Metformin (N, N-dimethylguanylguanidine) is one of the most prescribed drugs with
pleiotropic, exerted in part by not fully elucidated mechanisms of action. We developed and …
pleiotropic, exerted in part by not fully elucidated mechanisms of action. We developed and …
Timed function tests, motor function measure, and quantitative thigh muscle MRI in ambulant children with Duchenne muscular dystrophy: A cross-sectional analysis
S Schmidt, P Hafner, A Klein, D Rubino-Nacht… - Neuromuscular …, 2018 - Elsevier
The development of new therapeutic agents for the treatment of Duchenne muscular
dystrophy has put a focus on defining outcome measures most sensitive to capture treatment …
dystrophy has put a focus on defining outcome measures most sensitive to capture treatment …
Effect of combination l-citrulline and metformin treatment on motor function in patients with Duchenne muscular dystrophy: a randomized clinical trial
Importance Nitric oxide precursors, such as the amino acidl-arginine and the biguanide
antidiabetic drug metformin, have been associated with metabolism and muscle function in …
antidiabetic drug metformin, have been associated with metabolism and muscle function in …
Report on the workshop: meaningful outcome measures for Duchenne muscular dystrophy, London, UK, 30–31 January 2017
With the rapid increase in the number of interventional clinical trials in Duchenne muscular
dystrophy (DMD) over the past few years, the need for a frank and honest discussion …
dystrophy (DMD) over the past few years, the need for a frank and honest discussion …