Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

A link between oxidative stress and hypertension has been firmly established in multiple
animal models of hypertension but remains elusive in humans. While initial studies focused …

Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in
excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first …

The etiology of hypertension involves complex interactions among genetic, environmental,
and pathophysiologic factors that influence many regulatory systems. Hypertension is …

Low back pain (LBP) is a leading cause of labour loss and disability worldwide, and it also
imposes a severe economic burden on patients and society. Among symptomatic LBP …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Arterial stiffness progressively increases with aging and is an independent predictor of
cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the …