After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …

The PR/SET domain family (PRDM) comprise a family of genes whose protein products
share a conserved N-terminal PR [PRDI-BF1 (positive regulatory domain I-binding factor 1) …

Background—UK Biobank is the world's largest repository for phenotypic and genotypic
information for individuals of European ancestry. Here, we leverage UK Biobank to …

Drugs that kill tumors through multiple mechanisms have the potential for broad clinical
benefits. Here, we first developed an in silico multiomics approach (BipotentR) to find cancer …

Immune checkpoint inhibitor (ICI) therapy has revolutionised the treatment of various cancer
types. ICIs reinstate T-cell function to elicit an anti-cancer immune response. The resulting …

While MEF2 transcription factors are well known to cooperate in orchestrating cell fate and
adaptive responses during development and adult life, additional studies over the last …

Background The molecular factors which control circulating levels of inflammatory proteins
are not well understood. Furthermore, association studies between molecular probes and …

Objective Reduction of brain glucose transporter GLUT1 results in severe neurological
dysfunction. VEGF is required to restore and maintain brain glucose uptake across the blood …

Background Testosterone supplementation has been linked to increased cardiovascular
disease risk in some observational studies. The causal role of testosterone can be …

Objective Women with polycystic ovary syndrome (PCOS) have higher circulating levels of C-
reactive protein, but the relationship between inflammation and endocrine function in PCOS …