Abstract The 2 nd International Conference on Controversies in Vitamin D was held in
Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address …

Osteocytes are the most abundant (~ 95%) cells in bone with the longest half-life (~ 25
years) in humans. In the past osteocytes have been regarded as vestigial cells in bone …

Rickets refers to a deficient mineralization of the growth plate cartilage, predominantly
affecting longer bones. Despite the fact that preventive measures are available, it is still a …

Background Our earlier report indicated that active vitamin D3 inhibited epithelial-
mesenchymal transition (EMT) in bleomycin (BLM)-induced pulmonary fibrosis. The …

Throughout the world, millions of people suffer from fragilizing osteopathies such as
osteomalacia and osteoporosis. Osteomalacia is a rare disorder, corresponding to …

Although vitamin D deficiency resulting from insufficient sunlight exposure or inadequate
dietary vitamin D intake is the most common cause of rickets, mutations in genes involved in …

X-linked hypophosphatemia is the most common cause of inherited rickets, due to
inactivating variants of PHEX. More than 800 variants have been described to date and one …

Rare diseases are heterogeneous life-threatening or seriously debilitating conditions that
affect< 1 in 2000 individuals, and most have a genetic component. The diagnostic process is …

The mechanistic relationships between the progression of growth chondrocyte
differentiation, matrix mineralization, oxidative metabolism, and mitochondria content and …

Rickets results from impaired mineralization of growing bone due to alterations in calcium
and phosphate homeostasis. Clinical signs of rickets are related to the age of the patient, the …