Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …

Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

The breast is a dynamic organ whose response to physiological and pathophysiological
conditions alters its disease susceptibility, yet the specific effects of these clinical variables …

INTRODUCTION Tissue stem cells respond to and integrate environmental cues to
determine their fate and function. Injury induces radical changes in the microenvironment …

The epithelial–mesenchymal transition (EMT) program has emerged as a central driver of
tumor malignancy. Moreover, the recently uncovered link between passage through an EMT …

Cancer Stem Cells Cancers arise in tissues that can replicate and self-renew. Like normal
tissues, cancers can replenish themselves, grow, and metastasize because of stem cells that …

Despite major advances in understanding the molecular and genetic basis of cancer,
metastasis remains the cause of> 90% of cancer-related mortality. Understanding …

Recently, organoid technology has been used to generate a large repository of breast
cancer organoids. Here we present an extensive evaluation of the ability of organoid culture …