During the past three decades, mice, zebrafish, fruit flies, and Caenorhabditis elegans have
been the primary model organisms used for the study of various biological phenomena …

The clinical manifestations of cystic fibrosis (CF) result from dysfunction of the cystic fibrosis
transmembrane regulator protein (CFTR). The majority of people with CF have a limited life …

The pancreas is one of the earliest, and most commonly affected, organs in patients with
cystic fibrosis (CF). Studying the pathogenesis of pancreatic disease is limited in CF …

Cystic Fibrosis (CF), an autosomal recessive genetic disease, is caused by a mutation in the
gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). This …

Diabetes is a common complication of cystic fibrosis (CF) that affects approximately 20% of
adolescents and 40%–50% of adults with CF. The age at onset of CF-related diabetes …

Over the past 20 years it has become evident that eukaryotic cells utilize both conventional
and unconventional pathways to deliver proteins to their target sites. Most proteins with a …

Fully matured dental enamel is an architecturally and mechanically complex hydroxyapatite-
based bioceramic devoid of most of the organic material that was essential in its making …

Backgraoud & Aims Aberrant epithelial bicarbonate (HCO 3−) secretion caused by
mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene is …

The solute carrier SLC4 family consists of 10 members, nine of which are HCO 3-
transporters, including three Na+-independent Cl−/HCO 3-exchangers AE1, AE2, and AE3 …

The pancreas plays a central role in metabolism, allowing ingested food to be converted and
used as fuel by the cells throughout the body. On the other hand, the pancreas may be …