Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …
second most prevalent aortic disease following atherosclerosis, representing the ninth …
The mechanism and therapy of aortic aneurysms
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …
Epigenetic induction of smooth muscle cell phenotypic alterations in aortic aneurysms and dissections
BACKGROUND: Smooth muscle cell (SMC) phenotypic switching has been increasingly
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …
detected in aortic aneurysm and dissection (AAD) tissues. However, the diverse SMC …
Reactive Oxygen Species and Oxidative Stress in Vascular‐Related Diseases
XM Cheng, YY Hu, T Yang, N Wu… - Oxidative Medicine and …, 2022 - Wiley Online Library
Oxidative stress (OS) refers to the enhancement of oxidation and the decreased of related
antioxidant enzymes activity under pathological conditions, resulting in relatively excess …
antioxidant enzymes activity under pathological conditions, resulting in relatively excess …
Abdominal aortic aneurysm formation with a focus on vascular smooth muscle cells
Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease that affects,
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
mostly, the elder population, with a high mortality rate (> 80%) upon rupture. It features a …
[HTML][HTML] Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
MA Martínez, O Ritsvall, JA Bastrup, S Celik… - JCI insight, 2023 - ncbi.nlm.nih.gov
Inadequate adaption to mechanical forces, including blood pressure, contributes to
development of arterial aneurysms. Recent studies have pointed to a mechanoprotective …
development of arterial aneurysms. Recent studies have pointed to a mechanoprotective …
Gasdermin D deficiency in vascular smooth muscle cells ameliorates abdominal aortic aneurysm through reducing putrescine synthesis
J Gao, Y Chen, H Wang, X Li, K Li, Y Xu… - Advanced …, 2023 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …
N1-Methyladenosine (m1A) Regulation Associated With the Pathogenesis of Abdominal Aortic Aneurysm Through YTHDF3 Modulating Macrophage Polarization
Y Wu, D Jiang, H Zhang, F Yin, P Guo… - Frontiers in …, 2022 - frontiersin.org
Objectives This study aimed to identify key AAA-related m1A RNA methylation regulators
and their association with immune infiltration in AAA. Furthermore, we aimed to explore the …
and their association with immune infiltration in AAA. Furthermore, we aimed to explore the …
Dysregulations of key regulators of angiogenesis and inflammation in abdominal aortic aneurysm
D Zalewski, P Chmiel, P Kołodziej, G Borowski… - International Journal of …, 2023 - mdpi.com
Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …
Neutrophil extracellular traps induce abdominal aortic aneurysm formation by promoting the synthetic and proinflammatory smooth muscle cell phenotype via Hippo …
S Yang, L Chen, Z Wang, J Chen, Q Ni, X Guo… - Translational …, 2023 - Elsevier
The neutrophil plays an important role during abdominal aortic aneurysm (AAA) formation by
undergoing histone citrullination with peptidyl arginine deiminase 4 (encoded by Padi4) and …
undergoing histone citrullination with peptidyl arginine deiminase 4 (encoded by Padi4) and …