Myosins are motor proteins that use chemical energy to produce mechanical forces driving
actin cytoskeletal dynamics. In the brain, the conventional non-muscle myosin II (NMII) …

4-(1, 3-Benzothiazol-2-yl) thiophene-2-sulfonamide (4a) was found to be a moderately
potent inhibitor of cyclin-dependent kinase 5 (cdk5) from a HTS screen. The synthesis and …

Recent evidence suggests that endocytosis, not exocytosis, can be rate limiting for
neurotransmitter release at excitatory CNS synapses during sustained activity and therefore …

The DNA glycosylase NEIL2 plays a central role in maintaining genome integrity, in
particular during oxidative stress, by recognizing oxidized base lesions and initiating repair …

Transient receptor potential cation channel, subfamily A, member 1 (TRPA1), is activated by
a broad range of noxious stimuli. Cdk5, a member of the Cdk family, has recently been …

Cardiomyocyte migration represents a requisite event of cardiogenesis and the regenerative
response of the injured adult zebrafish and neonatal rodent heart. The present study tested …

Cyclin-dependent kinase5 (Cdk5), involved in the processes of neuronal maturation and
migration, is expressed in most tissues including proliferation cells. This research is aimed to …

细胞周期素依赖性蛋白激酶5 (cyclin dependent kinase-5, Cdk5) 是细胞周期素蛋白激酶之一,
具有很多磷酸化底物, 其激动剂p35 和p39 特异存在于神经系统(CNS). 因此, Cdk5 …

In order to survive and thrive in a hostile environment, organisms require the capacity to
detect and respond appropriately when potentially-harmful, tissuedamaging agents are …