Non-lethal outcomes of engaging regulated cell death pathways in cancer

H Kalkavan, S Rühl, JJP Shaw, DR Green - Nature Cancer, 2023 - nature.com
Regulated cell death (RCD) is essential for successful systemic cancer therapy. Yet, the
engagement of RCD pathways does not inevitably result in cell death. Instead, RCD …

The role of prostaglandins in different types of cancer

Á Jara-Gutiérrez, V Baladrón - Cells, 2021 - mdpi.com
The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from
polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have …

From conventional to precision therapy in canine mammary cancer: a comprehensive review

G Valdivia, Á Alonso-Diez, D Pérez-Alenza… - Frontiers in veterinary …, 2021 - frontiersin.org
Canine mammary tumors (CMTs) are the most common neoplasm in intact female dogs.
Canine mammary cancer (CMC) represents 50% of CMTs, and besides surgery, which is the …

Embryonal erythropoiesis and aging exploit ferroptosis

H Zheng, L Jiang, T Tsuduki, M Conrad, S Toyokuni - Redox biology, 2021 - Elsevier
Ferroptosis is a form of regulated cell necrosis, as a consequence of Fe (II)-dependent lipid
peroxidation. Although ferroptosis has been linked to cancer cell death, neurodegeneration …

Novel 1, 3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and …

AMM Shaker, MI Shahin, AM AboulMagd… - Bioorganic …, 2022 - Elsevier
Three series of novel 1-aryl-3-(4-methylsulfonylphenyl) pyrazole derivatives were
synthesized, characterized by several spectroscopic techniques, and investigated as …

Mechanisms of cancer cell death induction by triptolide

AH AbdulHussein, MM Al‐Taee, ZA Radih… - …, 2023 - Wiley Online Library
Drug resistance is a hot topic issue in cancer research and therapy. Although cancer therapy
including radiotherapy and anti‐cancer drugs can kill malignant cells within the tumor …

New pyrimidine-5-carbonitriles as COX-2 inhibitors: design, synthesis, anticancer screening, molecular docking, and in silico ADME profile studies

HA Al-Ghulikah, SA El-Sebaey, AKA Bass… - Molecules, 2022 - mdpi.com
Two series of cyanopyrimidine hybrids were synthesized bearing either benzo [d] imidazole,
benzo [d] oxazole, benzo [d] thiazole, and benzo [b] thiophene derivatives via methylene …

Cinnamomum zeylanicum Extract and its Bioactive Component Cinnamaldehyde Show Anti-Tumor Effects via Inhibition of Multiple Cellular Pathways

S Aggarwal, K Bhadana, B Singh, M Rawat… - Frontiers in …, 2022 - frontiersin.org
Cinnamomum zeylanicum is a tropical plant with traditional medicinal significance that
possesses antimicrobial, antifungal, anti-parasitic, and anti-tumor properties. Here, we have …

Potential of the Compounds from Bixa orellana Purified Annatto Oil and Its Granules (Chronic®) against Dyslipidemia and Inflammatory Diseases: In Silico Studies …

MA Batista, AVT de Lima Teixeira dos Santos… - Molecules, 2022 - mdpi.com
Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These
compounds have beneficial effects against hyperlipidemia and chronic diseases, where …

[HTML][HTML] Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

S Cotino-Nájera, LA Herrera… - Frontiers in …, 2023 - frontiersin.org
One of the primary diseases that cause death worldwide is cancer. Cancer cells can be
intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment …