Insomnia disorder affects a large proportion of the population on a situational, recurrent or
chronic basis and is among the most common complaints in medical practice. The disorder …

Chronic insomnia affects 57% of the elderly in the United States, with impairment of quality
of life, function, and health. Chronic insomnia burdens society with billions of dollars in direct …

Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
and may frequently be complicated by sleep disorders. Insomnia and obstructive sleep …

Sleep in chronic obstructive pulmonary disease (COPD) is commonly associated with
oxygen desaturation, which may exceed the degree of desaturation during maximum …

Introduction: Pulmonary rehabilitation (PR) is one of the core components in the
management of patients with chronic obstructive pulmonary disease (COPD). In order to …

Hypnotic effects of melatonin and melatoninergic drugs are mediated via MT1 and MT2
receptors, especially those in the circadian pacemaker, the suprachiasmatic nucleus, which …

Sleep problems are a common presenting symptom of elderly patients to primary care
physicians and psychiatrists. It is estimated that more than half of older adults have at least …

Respiration during sleep is regulated by circadian, endocrine, mechanical, and chemical
factors. The volitional control of breathing during wakefulness is abolished during sleep and …

Objective: As a melatonin receptor agonist, ramelteon has been approved in the United
States as a treatment for insomnia. As a potential alternation, ramelteon should be further …

Chronic obstructive pulmonary disease (COPD) prevalence is rising to epidemic proportions
due to historical smoking trends, the aging of the population, and air pollution. Although …