Phenothiazines as anti-cancer agents: SAR overview and synthetic strategies

A Kumar, C Vigato, D Boschi, ML Lolli… - European Journal of …, 2023 - Elsevier
Cancer is a leading cause of death worldwide and there are still limited options for cure.
Chemotherapy is the most significant treatment for cancer which increased survival rates …

Personalized treatment of glioblastoma: current state and future perspective

A Rončević, N Koruga, A Soldo Koruga, R Rončević… - Biomedicines, 2023 - mdpi.com
Glioblastoma (GBM) is the most aggressive glial tumor of the central nervous system.
Despite intense scientific efforts, patients diagnosed with GBM and treated with the current …

Efficacy and safety of chlorpromazine as an adjuvant therapy for glioblastoma in patients with unmethylated MGMT gene promoter: RACTAC, a phase II multicenter …

A Pace, G Lombardi, V Villani, D Benincasa… - Frontiers in …, 2023 - frontiersin.org
Introduction Drug repurposing is a promising strategy to develop new treatments for
glioblastoma. In this phase II clinical trial, we evaluated the addition of chlorpromazine to …

Drug repurposing, a fast-track approach to develop effective treatments for glioblastoma

I Ntafoulis, SLW Koolen, S Leenstra, MLM Lamfers - Cancers, 2022 - mdpi.com
Simple Summary Introducing novel and effective treatments against glioblastoma (GBM)
remains an arduous journey as reflected in the negative outcome of most clinical trials. The …

Molecular biology in glioblastoma multiforme treatment

C Abbruzzese, M Persico, S Matteoni, MG Paggi - Cells, 2022 - mdpi.com
Glioblastoma (GBM, grade IV astrocytoma), the most frequently occurring primary brain
tumor, presents unique challenges to therapy due to its location, aggressive biological …

Chlorpromazine affects glioblastoma bioenergetics by interfering with pyruvate kinase M2

C Abbruzzese, S Matteoni, P Matarrese… - Cell Death & …, 2023 - nature.com
Glioblastoma (GBM) is the most frequent and lethal brain tumor, whose therapeutic outcome-
only partially effective with current schemes-places this disease among the unmet medical …

Targeting the Essential Transcription Factor HP1043 of Helicobacter pylori: A Drug Repositioning Study

F Antoniciello, D Roncarati, A Zannoni… - Frontiers in Molecular …, 2022 - frontiersin.org
Antibiotic-resistant bacterial pathogens are a very challenging problem nowadays.
Helicobacter pylori is one of the most widespread and successful human pathogens since it …

Iloperidone and Temozolomide Synergistically Inhibit Growth, Migration and Enhance Apoptosis in Glioblastoma Cells

S Mubeen, I Raza, B Ujjan, B Wasim, L Khan, N Naeem… - Biomedicines, 2024 - mdpi.com
Glioblastoma (GBM) is a fatal astrocytic glioma with poor prognosis and treatment
resistance. Repurposing potential FDA-approved drugs like anti-psychotics can address the …

Combination Drug Therapy of Glioblastoma: Lessons from 3D In Vitro Models and the Roadmap for Future Research

M Vaezzadeh, E Kachooei… - Advanced …, 2023 - Wiley Online Library
Combination drug therapy addresses the auxiliary cancer pathways of the tumor
progression unaffected by the standard adjuvant treatments such as radio‐and …

Repurposing chlorpromazine as add-on in the adjuvant phase of first-line glioblastoma therapeutic protocol in patients carrying hypo-/un-methylated MGMT gene …

A Pace, G Lombardi, V Villani, D Benincasa… - medRxiv, 2023 - medrxiv.org
Background Glioblastoma (GBM) is a devastating brain tumor with poor prognosis,
characterized by rapid growth and invasion into surrounding brain tissue. It is a hard-to-treat …