[HTML][HTML] The epigenetic implication in coronavirus infection and therapy
S Atlante, A Mongelli, V Barbi, F Martelli, A Farsetti… - Clinical …, 2020 - Springer
Epigenetics is a relatively new field of science that studies the genetic and non-genetic
aspects related to heritable phenotypic changes, frequently caused by environmental and …
aspects related to heritable phenotypic changes, frequently caused by environmental and …
[HTML][HTML] The geroscience agenda: Toxic stress, hormetic stress, and the rate of aging
ES Epel - Ageing Research Reviews, 2020 - Elsevier
Geroscience offers a counterpoint to the challenged pursuit of curing diseases of aging, by
focusing on slowing the biological aging process for extended healthspan earlier in life …
focusing on slowing the biological aging process for extended healthspan earlier in life …
[HTML][HTML] HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19
M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial …
[HTML][HTML] Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease
The emergence of SARS-CoV-2 has created an international health crisis, and small animal
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …
models mirroring SARS-CoV-2 human disease are essential for medical countermeasure …
[HTML][HTML] Integrative respiratory follow-up of severe COVID-19 reveals common functional and lung imaging sequelae
A Froidure, A Mahsouli, G Liistro, J De Greef… - Respiratory …, 2021 - Elsevier
Background COVID-19 pandemic resulted in an unprecedented number of hospitalizations
in general wards and intensive care units (ICU). Severe and critical COVID-19 patients suffer …
in general wards and intensive care units (ICU). Severe and critical COVID-19 patients suffer …
COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia
TE Poloni, V Medici, M Moretti, SD Visonà… - Brain …, 2021 - Wiley Online Library
The actual role of SARS‐CoV‐2 in brain damage remains controversial due to lack of
matched controls. We aim to highlight to what extent is neuropathology determined by SARS …
matched controls. We aim to highlight to what extent is neuropathology determined by SARS …
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1
R Kandhaya‐Pillai, X Yang, T Tchkonia, GM Martin… - Aging cell, 2022 - Wiley Online Library
Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …
leading host risk factors for developing severe complications from COVID‐19 infection. The …
Underlying vulnerabilities to the cytokine storm and adverse COVID-19 outcomes in the aging immune system
LS Nidadavolu, JD Walston - The Journals of Gerontology …, 2021 - academic.oup.com
Older adults are far more vulnerable to adverse health outcomes and mortality after
contracting COVID-19. There are likely multiple age-related biological, clinical, and …
contracting COVID-19. There are likely multiple age-related biological, clinical, and …
[HTML][HTML] Comorbidities and increased mortality of COVID-19 among the elderly: A systematic review
Purpose The purpose of current review is to conduct a systematic overview of articles
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
published between 2019 and 2021 on the relationship of comorbidities and mortality due to …
[HTML][HTML] Telomeres and mitochondrial metabolism: implications for cellular senescence and age-related diseases
X Gao, X Yu, C Zhang, Y Wang, Y Sun, H Sun… - Stem cell reviews and …, 2022 - Springer
Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …