The strength of male-driven evolution–that is, the magnitude of the sex ratio of mutation rate–
has been a controversial issue, particularly in primates. While earlier studies estimated the …

Men have more germ-line cell divisions than women. Does this lead to a higher mutation
rate in males? Most estimates of the proportion of mutations originating in men come either …

In many instances, there are large sex differences in mutation rates, recombination rates,
selection, rates of gene flow, and genetic drift. Mutation rates are often higher in males, a …

The clinical manifestation of hemophilia A is caused by a wide range of different mutations.
In this study the factor VIII genes of 147 severe hemophilia A patients--all exclusively from …

A large number of different mutations in the factor VIII (F8) gene have been identified as a
cause of haemophilia A. This compilation lists known single base-pair substitutions …

Life‐history traits vary substantially across species, and have been demonstrated to affect
substitution rates. We compute genome‐wide, branch‐specific estimates of male mutation …

Background In a small group of typical hemophilia A (HA) patients no mutations in the F8
coding sequence (cDNA) could be found. In the current study, we performed a systematic …

Abstract Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-chromosomal
storage disorder due to deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS). We …

Genes shared between the nonrecombining parts of the two types of sex chromosomes offer
a potential means to study the molecular evolution of the same gene exposed to different …

Base substitution mutations are far more common in human males than in females, and the
frequency increases with paternal age. Both can be accounted for by the greater number of …