Executive summary The number of older people, including those living with dementia, is
rising, as younger age mortality declines. However, the age-specific incidence of dementia …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by the
accumulation of amyloid β in the form of extracellular plaques and by intracellular …

Cognitive impairment is an increasingly recognized major cause of chronic disability and is
commonly found in patients with chronic kidney disease (CKD). Knowledge of the …

Alzheimer's disease acknowledged as progressive multifarious neurodegenerative disorder,
is the leading cause of dementia in late adult life. Pathologically it is characterized by …

The discovery of vitamin E will have its 100th anniversary in 2022, but we still have more
questions than answers regarding the biological functions and the essentiality of vitamin E …

The construct of mild cognitive impairment (MCI) has evolved over the past 10 years since
the publication of the new MCI definition at the K ey S ymposium in 2003, but the core …

Background Dementia is a progressive global cognitive impairment syndrome. In 2010,
more than 35 million people worldwide were estimated to be living with dementia. Some …

A systematic review was conducted to identify risk factors associated with the onset and
progression of Alzheimer's disease (AD). Moderate and high quality systematic reviews …