Inborn errors of immunity (IEI), formerly known as primary immunodeficiency disorders
(PIDs), are inherited disorders caused by damaging germline variants in single genes …

Primary atopic disorders describes a series of monogenic diseases that have allergy-or
atopic effector–related symptoms as a substantial feature. The underlying pathogenic …

Inborn errors of immunity (IEI) are a heterogeneous group of disorders, mainly resulting from
mutations in genes associated with immunoregulation and immune host defense. These …

The proper regulation of IgE production safeguards against allergic disease, highlighting the
importance of mechanisms that restrict IgE plasma cell (PC) survival. IgE PCs have …

Common variable immunodeficiency disorders refer to a relatively common primary immune
deficiency group of diseases that present with infectious and inflammatory complications …

CARD11 is a multidomain scaffold protein required for normal activation of NF-κB, JNK, and
mTOR during Ag receptor signaling. Germline CARD11 mutations cause at least three types …

Background Monogenic conditions that disrupt proper development and/or function of the
immune system are termed inborn errors of immunity (IEIs), also known as primary …

Transcription factors are an extremely important group of proteins that are responsible for
the process of selective activation or deactivation of other cellular proteins, usually at the last …

Introduction: Inborn errors of immunity (IEIs) are rare inherited disorders with a broad
spectrum of manifestations. Here, we aimed to delineate the atopy burden in a cohort of …

Background Inborn errors of immunity (IEIs) are a group of conditions affecting immune
system development and function. Due to their clinical heterogeneity and lack of provider …