Numerous chronic diseases have a substantial hereditary component. Recent advances in
human genetics have allowed the extent of this to be quantified via genome-wide …

Background Cancers are a large and heterogeneous group of malignant tumors that
collectively accounted for approximately 600 000 US deaths in 2020; only heart disease …

Deciphering the genetic relationships between major depressive disorder (MDD) and
insomnia may facilitate understanding biological mechanisms as well as inform more …

Background Chronic obstructive pulmonary disease (COPD) is caused by interactions
between many factors across the life course, including genetics. A proportion of COPD may …

Pharmacogenomics (PGx) aims at tailoring drug therapy by considering patient genetic
makeup. While drug dosage guidelines have been extensively based on single gene …

Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer
factor (TCF/LEF) family, plays an important role in normal human physiological and …

The relationship between psoriasis and site-specific cancers remains unclear. Here, we aim
to investigate whether psoriasis is causally associated with site-specific cancers. We use …

Gestational diabetes mellitus (GDM) is a common complication of pregnancy that adversely
affects maternal and offspring health. A variety of risk factors, such as BMI and age, have …

Background Previous studies have shown that three DNA methylation (DNAm) based
algorithms of aging, DNAm PhenoAge acceleration (AgeAccelPheno), DNAm GrimAge …

Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that arises
from multiple causes, including sepsis, pneumonia, trauma, and severe coronavirus disease …