Introduction: Variability of drug response is an important consideration in clinical medicine. A
major determinant of drug response variability is hepatic cytochrome P450 oxidase …

Abstract Background: Recent Food and Drug Administration legislation enables the
mandating of product performance standards for cigarette smoke and the evaluation of …

Considered the most comprehensive handbook in the field, this rich resource reviews the
biological, psychological, and social factors that affect health, health behavior, and illness …

This chapter summarizes genetic factors that contribute to variation in nicotine
pharmacokinetics and nicotine's pharmacological action in the central nervous system …

Tobacco smoke contains more than 4000 detectable substances, such as polycyclic
aromatic hydrocarbons, nicotine, carbon monoxide and heavy metals, which are considered …

In recent years, the mode of alcoholic intake known as binge drinking (BD) has become a
common practice, especially among adolescents who, due to socio-environmental motives …

Introduction Identifying genetic factors associated with smoking cessation could inform
precision cessation interventions. Of major interest is genetic variation in nicotine …

Human cytochrome P4502B6 (CYP2B6) is predominantly expressed in the liver and it plays
a major role in the metabolism of several therapeutically important drugs and environmental …

Many smokers attempt to quit smoking but few are successful in the long term. The
heritability of nicotine addiction and smoking relapse have been documented, and research …

Introduction: Smoking remains a worldwide epidemic, and despite an increase in public
acceptance of the harms of tobacco use, it remains the leading cause of preventable death …