Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes

E Bossone, KA Eagle - Nature Reviews Cardiology, 2021 - nature.com
The aorta is the 'greatest artery', through which oxygenated blood is delivered from the left
ventricle to end organs with each cardiac cycle (200 million litres of blood transported in an …

Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Neutrophils as regulators and biomarkers of cardiovascular inflammation in the context of abdominal aortic aneurysms

J Klopf, C Brostjan, C Neumayer, W Eilenberg - Biomedicines, 2021 - mdpi.com
Neutrophils represent up to 70% of circulating leukocytes in healthy humans and combat
infection mostly by phagocytosis, degranulation and NETosis. It has been reported that …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

[HTML][HTML] Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery

A Busch, S Bleichert, N Ibrahim, M Wortmann… - JVS-vascular …, 2021 - Elsevier
Introduction Abdominal aortic aneurysm (AAA) is a condition that has considerable
socioeconomic impact and an eventual rupture is associated with high mortality and …

Association of serum lipoprotein (a) with the requirement for a peripheral artery operation and the incidence of major adverse cardiovascular events in people with …

J Golledge, S Rowbotham, R Velu… - Journal of the …, 2020 - Am Heart Assoc
Background The aim of this study was to assess the relationship between serum lipoprotein
(a)(Lp [a]) concentration and the requirement for peripheral artery disease (PAD) operations …