[HTML][HTML] Protein tyrosine kinases: their roles and their targeting in leukemia

K K. Bhanumathy, A Balagopal, FS Vizeacoumar… - Cancers, 2021 - mdpi.com
Simple Summary Protein phosphorylation is a key regulatory mechanism that controls a
wide variety of cellular responses. This process is catalysed by the members of the protein …

Thyroid dysfunction caused by second-generation tyrosine kinase inhibitors in Philadelphia chromosome-positive chronic myeloid leukemia

TD Kim, M Schwarz, H Nogai, P Grille, J Westermann… - Thyroid, 2010 - liebertpub.com
Background: Thyroid dysfunction is a well-known adverse effect of first-generation tyrosine
kinase inhibitors (TKIs), like sunitinib. The aim of this study was to investigate the effect of …

[HTML][HTML] Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive …

TD Kim, S Türkmen, M Schwarz, G Koca, H Nogai… - …, 2010 - ncbi.nlm.nih.gov
Background Additional chromosomal aberrations in Philadelphia chromosome-positive
chronic myeloid leukemia are non-random and strongly associated with disease …

Clonal chromosomal abnormalities in Philadelphia-negative cells in chronic myeloid leukemia patients treated with nilotinib used in first-line therapy

H Wang, J Jin, Y Wang, X Huang, J Huang - Annals of hematology, 2013 - Springer
Nilotinib is an effective option for the first-line treatment of chronic myeloid leukemia (CML)
patients in chronic phase (CP). In CML patients, clonal cytogenetic abnormalities (CAs) in …

Nilotinib

A Quintás-Cardama, TD Kim, V Cataldo… - Small Molecules in …, 2009 - Springer
Therapy with imatinib mesylate is a standard of care for most patients with Philadelphia
chromosome-positive chronic myeloid leukemia (CML). However, resistance or intolerance …

[PDF][PDF] Protein Tyrosine Kinases: Their Roles and Their Targeting in Leukemia. Cancers 2021, 13, 184

FS Vizeacoumar, FJ Vizeacoumar, A Freywald… - 2021 - pdfs.semanticscholar.org
Protein kinases constitute a large group of enzymes catalysing protein phosphorylation and
controlling multiple signalling events. The human protein kinase superfamily consists of 518 …

[引用][C] Thyroid Dysfunction caused by Tyrosine Kinase Inhibitors in Philadelphia Chromosome Positive Chronic Myeloid Leukemia

M Amaravathi - 2016 - Madras Medical College, Chennai