COVID-19 pandemic and vaccines update on challenges and resolutions

WH Khan, Z Hashmi, A Goel, R Ahmad… - Frontiers in cellular …, 2021 - frontiersin.org
The coronavirus disease (COVID-19) is caused by a positive-stranded RNA virus called
severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), belonging to the …

An updated review of SARS-CoV-2 vaccines and the importance of effective vaccination programs in pandemic times

C García-Montero, O Fraile-Martínez, C Bravo… - Vaccines, 2021 - mdpi.com
Since the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines
has become the top priority in order to restore normalcy after 2.5 million deaths worldwide …

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

Y Zhang, V Bharathi, T Dokoshi… - Proceedings of the …, 2024 - National Acad Sciences
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …

Catalytic dyad residues His41 and Cys145 impact the catalytic activity and overall conformational fold of the main SARS-CoV-2 protease 3-chymotrypsin-like protease

JC Ferreira, S Fadl, AJ Villanueva, WM Rabeh - Frontiers in chemistry, 2021 - frontiersin.org
Coronaviruses are responsible for multiple pandemics and millions of deaths globally,
including the current pandemic of coronavirus disease 2019 (COVID-19). Development of …

Mast cell-mediated immune regulation in health and disease

KN Dileepan, VV Raveendran, R Sharma… - Frontiers in …, 2023 - frontiersin.org
Mast cells are important components of the immune system, and they perform pro-
inflammatory as well as anti-inflammatory roles in the complex process of immune regulation …

Cytokine storm syndrome in SARS-CoV-2 infections: a functional role of mast cells

B Hafezi, L Chan, JP Knapp, N Karimi, K Alizadeh… - Cells, 2021 - mdpi.com
Cytokine storm syndrome is a cascade of escalated immune responses disposing the
immune system to exhaustion, which might ultimately result in organ failure and fatal …

Mechanism and Application of Surface-Charged Ferrite Nanozyme-Based Biosensor toward Colorimetric Detection of l-Cysteine

H Wu, J Liu, Z Chen, P Lin, W Ou, Z Wang, W Xiao… - Langmuir, 2022 - ACS Publications
Peroxidase-like nanozymes with robust catalytic capacity and detection specificity have
been proposed as substitutes to natural peroxidases in biochemical sensing. However, the …

In silico validation of anti-viral drugs obtained from marine sources as a potential target against SARS-CoV-2 Mpro

S Ghosh, S Das, I Ahmad, H Patel - Journal of the Indian Chemical Society, 2021 - Elsevier
COVID-19 caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
has threatened the whole world affecting almost 243 million people globally. Originating …

COVID-19 as a trigger for type 1 diabetes

Y Wang, H Guo, G Wang, J Zhai… - The Journal of Clinical …, 2023 - academic.oup.com
Abstract Type 1 diabetes (T1D) is usually caused by immune-mediated destruction of islet β
cells, and genetic and environmental factors are thought to trigger autoimmunity. Convincing …

The current status of drug repositioning and vaccine developments for the COVID-19 pandemic

JH Won, H Lee - International Journal of Molecular Sciences, 2020 - mdpi.com
Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world
has vehemently worked to develop treatments and vaccines against severe acute …