Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Diabetic neuropathy, with its major clinical sequels, notably neuropathic pain, foot ulcers,
and autonomic dysfunction, is associated with substantial morbidity, increased risk of …

Neuropathy is the most common complication of diabetes. As a consequence of
longstanding hyperglycemia, a downstream metabolic cascade leads to peripheral nerve …

Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …

Neuropathy is the most common and debilitating complication of diabetes and results in
pain, decreased motility, and amputation. Diabetic neuropathy encompasses a variety of …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

The prevalence of diabetes mellitus and its chronic complications continue to increase
alarmingly. Consequently, the massive expenditure on diabetic distal symmetrical …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …