Diabetic neuropathy (DN) is a common long‐term complication of type 1 (T1D) and type 2
(T2D) diabetes mellitus, with significant morbidity and mortality. DN is defined as impaired …

Aims/hypothesis Evidence for the importance of peroxynitrite, a product of superoxide anion
radical reaction with nitric oxide, in peripheral diabetic neuropathy is emerging. The role of …

Pioglitazone, one of thiazolidinediones, a peroxisome proliferator‐activated receptor (PPAR)‐
γ ligand, is known to have beneficial effects on macrovascular complications in diabetes, but …

Nicotinamide adenine dinucleotide (NAD+) is an omnipresent metabolite that participates in
redox reactions. Multiple NAD+-consuming enzymes are implicated in numerous biological …

Abstract Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene
located on chromosome 1 (1q42. 12) in human cells. It plays a crucial role in post …

We have previously shown that treating streptozotocin-induced diabetic rats, an animal
model of type 1 diabetes, with Ilepatril (an inhibitor of neutral endopeptidase and …

Diabetic autonomic neuropathy (DAN) represents a major complication of diabetes mellitus
but there is considerable uncertainty about its incidence, prevalence, pathogenesis …

Neuropathic pain is a debilitating pathological pain condition with a great therapeutic
challenge in clinical practice. Currently used analgesics produce deleterious side effects …

Diabetic polyneuropathy (DPN) is a common but intractable degenerative disorder of
peripheral neurons. DPN first results in retraction and loss of sensory terminals in target …

Diabetic neuropathy is a neuro-degenerative disorder that encompasses numerous factors
that impact peripheral nerves in the context of diabetes mellitus (DM). Diabetic peripheral …