Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

In this narrative review, a theoretical framework on the crosstalk between physical exercise
and blood-brain barrier (BBB) permeability is presented. We discuss the influence of …

Societies are progressively aging, with the oldest old (ie., those aged> 80–85 years) being
the most rapidly expanding population segment. However, advanced aging comes at a …

Regular exercise is associated with pronounced health benefits. The molecular processes
involved in physiological adaptations to exercise are best understood in skeletal muscle …

In the last few years, the muscular system has gained attention due to the discovery of the
muscle-secretome and its high potency for retaining or regaining health. These cytokines …

Physical activity reduces cardiometabolic risk, while physical inactivity increases chronic
diseases risk. This led to the idea that exercise-induced muscle contraction contributes to …

Physical exercise has gradually become a focus in cancer treatment due to its pronounced
role in reducing cancer risk, enhancing therapeutic efficacy, and improving prognosis. In …

Irisin is a myokine derived from the cleavage of fibronectin type III domain-containing 5. Irisin
regulates mitochondrial energy, glucose metabolism, fatty acid oxidation, and fat browning …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

According to Alzheimer's Disease International, 55 million people worldwide are living with
dementia. Dementia is a disorder that manifests as a set of related symptoms, which usually …