Mechanisms and Regulation of Neuronal GABAB Receptor-Dependent Signaling

TR Rose, K Wickman - Behavioral Neurobiology of GABAB Receptor …, 2020 - Springer
Abstract γ-Aminobutyric acid B receptors (GABABRs) are broadly expressed throughout the
central nervous system where they play an important role in regulating neuronal excitability …

[HTML][HTML] Unravelling biological roles and mechanisms of GABABR on addiction and depression through mood and memory disorders

YS Wang, TY Qiu, Q Fu, SQ Xiong, ZZ Wang… - Biomedicine & …, 2022 - Elsevier
The metabotropic γ-aminobutyric acid type B receptor (GABA BR) remains a hotspot in the
recent research area. Being an idiosyncratic G-protein coupled receptor family member, the …

Direct interaction of PP2A phosphatase with GABAB receptors alters functional signaling

X Li, M Terunuma, TG Deeb, S Wiseman… - Journal of …, 2020 - Soc Neuroscience
Addictive drugs usurp the brain9s intrinsic mechanism for reward, leading to compulsive and
destructive behaviors. In the ventral tegmental area (VTA), the center of the brain9s reward …

GABAB receptor/HCN channel complexes in VTA dopamine neurons limit synaptic inhibition and prevent anxiety-like behavior

E Pérez-Garci, G Rizzi, T Fritzius, A Porcu… - bioRxiv, 2021 - biorxiv.org
Aversive stimuli inhibiting dopamine neurons in the ventral tegmental area (DAVTA
neurons) induce anxiety-like behaviors. The inhibition of DAVTA neurons is prolonged by …

Relevance of inhibitory G protein-dependent signaling in prelimbic pyramidal neurons to cocaine-related behavior

TR Rose - 2022 - search.proquest.com
Drugs of abuse share the ability to enhance DA levels within the mesocorticolimbic system.
This increased DA neurotransmission triggers persistent adaptations throughout the brain …

Differential Control of Potassium Channel Activity by GRK2

A Raveh, L Guy-David, E Reuveny - G Protein-Coupled Receptor Kinases, 2016 - Springer
Extending their accepted role in downregulating GPCRs from the cell membrane following
GPCR activation, GRK shows an additional novel role, to rapidly control GPCRs activation of …

GABAB receptor-associated KCTD proteins as molecular linkers to downstream signaling complexes

D Berner - 2016 - edoc.unibas.ch
GABAB receptors are metabotropic receptors of the prevalent inhibitory neurotransmitter
gammaaminobutyric acid (GABA), playing important roles in modulating overall …