[HTML][HTML] Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials

M Pfau, JK Jolly, Z Wu, J Denniss, EM Lad… - Progress in Retinal and …, 2021 - Elsevier
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …

[HTML][HTML] Artificial intelligence algorithms for analysis of geographic atrophy: a review and evaluation

J Arslan, G Samarasinghe, KK Benke… - … vision science & …, 2020 - iovs.arvojournals.org
Purpose: The purpose of this study was to summarize and evaluate artificial intelligence (AI)
algorithms used in geographic atrophy (GA) diagnostic processes (eg isolating lesions or …

Progression of photoreceptor degeneration in geographic atrophy secondary to age-related macular degeneration

M Pfau, L von der Emde, L de Sisternes… - JAMA …, 2020 - jamanetwork.com
Importance Sensitive outcome measures for disease progression are needed for treatment
trials in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) …

Association of complement C3 inhibitor pegcetacoplan with reduced photoreceptor degeneration beyond areas of geographic atrophy

M Pfau, S Schmitz-Valckenberg, R Ribeiro, R Safaei… - Scientific Reports, 2022 - nature.com
Preservation of photoreceptors beyond areas of retinal pigment epithelium atrophy is a
critical treatment goal in eyes with geographic atrophy (GA) to prevent vision loss. Thus, we …

Prediction of visual function from automatically quantified optical coherence tomography biomarkers in patients with geographic atrophy using machine learning

K Balaskas, S Glinton, TDL Keenan, L Faes, B Liefers… - Scientific reports, 2022 - nature.com
Geographic atrophy (GA) is a vision-threatening manifestation of age-related macular
degeneration (AMD), one of the leading causes of blindness globally. Objective, rapid …

Automated quantitative assessment of retinal fluid volumes as important biomarkers in neovascular age-related macular degeneration

TDL Keenan, U Chakravarthy, A Loewenstein… - American journal of …, 2021 - Elsevier
Purpose To evaluate retinal fluid volume data extracted from optical coherence tomography
(OCT) scans by artificial intelligence algorithms in the treatment of neovascular age-related …

Development and validation of a machine learning-based nomogram for prediction of ankylosing spondylitis

J Zhu, Q Lu, T Liang, JieJiang, H Li, C Zhou… - Rheumatology and …, 2022 - Springer
Introduction Ankylosing spondylitis (AS) is a chronic progressive inflammatory disease of the
spine and its affiliated tissues. AS mainly affects the axial bone, sacroiliac joint, hip joint …

Association of reading performance in geographic atrophy secondary to age-related macular degeneration with visual function and structural biomarkers

SH Künzel, M Lindner, J Sassen, PT Möller… - JAMA …, 2021 - jamanetwork.com
Importance As a disabling and frequent disease, geographic atrophy secondary to age-
related macular degeneration (AMD) constitutes an important study subject. Emerging …

[HTML][HTML] Probabilistic forecasting of anti-VEGF treatment frequency in neovascular age-related macular degeneration

M Pfau, S Sahu, RA Rupnow… - … Vision Science & …, 2021 - iovs.arvojournals.org
Purpose: To probabilistically forecast needed anti-vascular endothelial growth factor (anti-
VEGF) treatment frequency using volumetric spectral domain–optical coherence …

[HTML][HTML] Linking function and structure with ReSensNet: predicting retinal sensitivity from OCT using deep learning

P Seeböck, WD Vogl, SM Waldstein, JI Orlando… - Ophthalmology …, 2022 - Elsevier
Purpose The currently used measures of retinal function are limited by being subjective,
nonlocalized, or taxing for patients. To address these limitations, we sought to develop and …