Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …

Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy.
The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) …

Lysosomes are catabolic organelles that contribute to the degradation of intracellular
constituents through autophagy and of extracellular components through endocytosis …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) continues to rise, yet
effective treatments are lacking due to the complex pathogenesis of this disease. Although …

Elevated levels of plasma branched-chain amino acids (BCAAs) have been associated with
insulin resistance and type 2 diabetes since the 1960s. Pharmacological activation of …