Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlapping pathologic processes activate a common pathway consisting of endothelial cell …

Hypertensive disorders of pregnancy (HDP) remain one of the major causes of pregnancy-
related maternal and fetal morbidity and mortality worldwide. Affected women are also at …

Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

This statement summarizes evidence that adverse pregnancy outcomes (APOs) such as
hypertensive disorders of pregnancy, preterm delivery, gestational diabetes, small-for …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

The development of human gut microbiota begins as soon as the neonate leaves the
protective environment of the uterus (or maybe in-utero) and is exposed to innumerable …

It is a lesser-known fact that metformin was originally introduced as an anti-influenza drug
and that glucose-lowering was only one of its side effects [1]. The many pleiotropic effects of …

Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy
complications with similar risk factors and pathophysiological changes. Evidence from …

Background: Diabetes reduces semen quality and increasingly occurs during reproductive
years. Diabetes medications, such as metformin, have glucose-independent effects on the …

Metformin is a lipophilic biguanide which inhibits hepatic gluconeogenesis and improves
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …