T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …

Several studies have demonstrated that memory T cells including stem cell memory (Tscm)
T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity …

The PD-1 pathway is a cornerstone in immune regulation. While the PD-1 pathway has
received considerable attention for its role in contributing to the maintenance of T cell …

R-2-hydroxyglutarate accumulates to millimolar levels in cancer cells with gain-of-function
isocitrate dehydrogenase 1/2 mutations. These levels of R-2-hydroxyglutarate affect 2 …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

The molecules of Major histocompatibility class I (MHC-I) load peptides and present them on
the cell surface, which provided the immune system with the signal to detect and eliminate …

Memory CD8 T cells are a critical component of protective immunity, and inducing effective
memory T-cell responses is a major goal of vaccines against chronic infections and …

Memory T cells are critical for long-term immunity against reinfection and require interleukin-
7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly …

Summary T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the
canonical Wnt pathway and is essential for normal T cell development. However, its …

Vaccines work by eliciting an immune response and consequent immunological memory
that mediates protection from infection or disease. Recently, new methods have been …